KNEE

CARTIHEAL AGILI C Cartilage Repair Implant Cartilage Repair Implant

Learn about a new treatment to repair cartilage and bone in the knee. The CARTIHEAL AGILI-C Cartilage Repair Implant is changing the game on knee repair.

Overview

The CARTIHEAL AGILI-C Cartilage Repair Implant is designed to repair damage in the cartilage and bone of the knee, including damage caused by arthritis. Patients treated with the CARTIHEAL AGILI-C Implant have reported significant relief of knee pain and improved knee function.^1-2*

What is the CARTIHEAL AGILI-C Implant?

The CARTIHEAL AGILI-C Implant is designed to help grow new tissue in the knee to treat damaged cartilage and bone. It’s a small implant that gets inserted into damaged cartilage and serves as “scaffolding” for the growth of new tissue.^1,3-7 Over time, the implant is resorbed by the body.^1,3,5 The new cartilage remains.

CARTIHEAL AGILI-C Implant in the News

The CARTIHEAL AGILI-C Cartilage Repair Implant was recently featured in a news story by CBS News. Watch the video to hear doctors talk about the implant – how it works, what it’s made of, and how it may help patients with knee pain who are not ready for knee replacement. The video also includes patients who have been treated with the implant, one saying that she has been “elated” with the results.

This story is for informational purposes only. Knee products may not be suitable for all patients; results may vary. Consult your physician to determine if the products discussed in this video are appropriate for your condition. Smith+Nephew is not affiliated with CBS News; video rights belong to respective owners.

Watch the CBS News Story on YouTube

This link leads from the Smith+Nephew website to a YouTube channel operated by CBS News. The channel is not affiliated with, endorsed by, or under the control of Smith+Nephew. Smith+Nephew is not responsible for the content or availability of external sites.

CARTIHEAL AGILI-C Implant patient success stories

Learn more through the stories of real patients who have found relief from knee pain with the CARTIHEAL AGILI-C Implant.

Chris

Busy professional and family man, now back to big adventures after treatment with the CARTIHEAL AGILI-C Implant.

The patient testimonial(s) depicted represent the individual patient’s own opinions, findings, beliefs, and/or experiences. Individual results will vary. Not everyone who receives a product or treatment will experience the same or similar results; results may vary depending on a number of factors, including each patient’s specific circumstances and condition, and compliance with the applicable Instructions for Use. Smith+Nephew is not responsible for the selection of any treatment by a healthcare professional to be used on a particular patient. Smith+Nephew makes no representations, warranties, guarantees or assurances as to the availability, accuracy, currency or completeness of the information presented or its contents.

What are the benefits of the CARTIHEAL AGILI-C Implant?

The CARTIHEAL AGILI-C Implant has been shown to provide positive results for patients, including improvements in pain, function, and quality of life:^1,2*

Is the CARTIHEAL AGILI-C Implant right for me?

To find out if the CARTIHEAL AGILI-C Implant is a treatment option, make an appointment with an orthopaedic surgeon. The surgeon will examine your knee and review your health situation in determining if cartilage repair is recommended.

How does it work?

Treatment with the CARTIHEAL AGILI-C Implant involves a surgical procedure. These are the typical steps in the process:

(Results will vary. These are representative drawings only, not actual surgical results.)

Results will vary. These are representative drawings only, not actual surgical results.

Supporting information

What are the risks involved?

There may be complications when you have this surgery. The risks and side effects associated with the CARTIHEAL Agili-C Implant are similar to the risks associated with similar types of orthopedic surgical treatments and include the following:

Temporary or ongoing pain
Temporary or ongoing swelling or inflammation at the surgical site
Temporary or ongoing limited range of motion, stiffness
Fever
Allergic response
Bone fracture
Bone deformity
The implant might loosen, break, or tear due to an accident or activity
Infection on the surface of the incision or within the wound itself
Bruising

Talk to your surgeon to learn more about the possible risks for your specific health situation.

Disclaimers

^* Over 2 and 4 year follow-up; compared to standard of care (microfracture or debridement).

All information provided on this website is for informational purposes only and is not meant as medical advice. Not everyone is a candidate for knee repair with the CARTIHEAL AGILI-C Cartilage Repair Implant, and individual results will vary. Every patient’s case is unique, and each patient should follow his or her doctor’s specific instructions. Potential risks include infection, transient or chronic pain, and swelling, among others, that may result in the need for additional medical intervention. Discuss your condition and options with your surgeon. If you are seeking this information in an emergency situation, please call 911 and seek emergency help.

^◊Trademark of Smith+Nephew. 46750 3/2025

Citations

Altschuler N, Zaslav KR, Di Matteo B, et al. Aragonite-Based Scaffold Versus Microfracture and Debridement for the Treatment of Knee Chondral and Osteochondral Lesions: Results of a Multicenter Randomized Controlled Trial. Am J Sports Med. 2023;51(4):957-967.
Conte P, Anzillotti G, Crawford DC, et al. Differential analysis of the impact of lesions' location on clinical and radiological outcomes after the implantation of a novel aragonite-based scaffold to treat knee cartilage defects. Int Orthop. 2024;48(12):3117-3126.
Kon E, Di Matteo B, Verdonk P, et al. Aragonite-Based Scaffold for the Treatment of Joint Surface Lesions in Mild to Moderate Osteoarthritic Knees: Results of a 2-Year Multicenter Prospective Study. Am J Sports Med. 2021;49(3):588-598.
Kon E, Filardo G, Shani J, et al. Osteochondral regeneration with a novel aragonite-hyaluronate biphasic scaffold: up to 12-month follow-up study in a goat model. J Orthop Surg Res. 2015;10:81.
Kon E, Robinson D, Verdonk P, et al. A novel aragonite-based scaffold for osteochondral regeneration: early experience on human implants and technical developments. Injury. 2016;47 Suppl 6:S27-S32.
Chubinskaya S, Di Matteo B, Lovato L, Iacono F, Robinson D, Kon E. Agili-C implant promotes the regenerative capacity of articular cartilage defects in an ex vivo model. Knee Surg Sports Traumatol Arthrosc. 2019;27(6):1953-1964.
Matta C, Szűcs-Somogyi C, Kon E, et al. Osteogenic differentiation of human bone marrow-derived mesenchymal stem cells is enhanced by an aragonite scaffold. Differentiation. 2019;107:24-34.
Smith+Nephew. CARTIHEAL Agili-C Implant Device Lifetime Memo. RDD-0001641. 2024.

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