SPORTS MEDICINE
REGENETEN◊ Bioinductive Implant
Bioengineered collagen scaffold for tendon repair.1-3 Resorbed and replaced by new tendon-like tissue within 6 months to support tendon healing.1,2,4-7
Redefining biological healing
The REGENETEN Bioinductive Implant is a bioengineered scaffold made from highly purified type I collagen fibers. Following fixation using its efficient & suture-free technique, the REGENETEN Implant is resorbed and replaced by a new layer of tendon-like tissue within 6 months1,2,4,5 increasing tendon thickness.1,2,4-7 and creating an environment conducive to healing.1,6,7
A decade of data has demonstrated a powerful impact on clinical outcomes.6,11 As an isolated treatment, the REGENETEN Implant has been shown to lead to accelerated recovery5,8 & consistent tendon healing6,10 in partial-thickness tears. As an augment to repair in full-thickness tears, the REGENETEN Implant has been shown to lead to a reduction in postoperative re-tear rates.9
How the REGENETEN Implant works
The REGENETEN Implant serves as a scaffold for new tendon-like tissue growth1,2,4,5, increasing tendon thickness.1,2,4-7
The REGENETEN Implant can also be used tendons around the body. Please click the links below to deepen your learning on how it is used in the foot & ankle and hip anatomies:
REGENETEN Implant Patient Success Stories
The REGENETEN Implant has been used in more than 150,000 patients globally. Please see the videos below to hear some of their stories
Dr. Owen Shea
Outdoorsman and anaesthesiologist who received the REGENTEN implant following a complex full-thickness rotator cuff tear
Francois
Devoted cyclist whose shoulder never quite got back to normal after road-bike accident. Hear about how REGENETEN allowed him to get back on the road.
Nick
High school teacher and “coach-dad” who was able to recover from a partial-thickness tear with the help of the REGENETEN Implant
Emily
Avid golfer, loving mom and S+N employee who sought out the REGENETEN Implant when she was suffering from a shoulder injury
News and Announcements
Medical Education
To learn more about our S+N Sports Medicine portfolio, please visit our Shoulder Repair Page on VuMedi
No results.
Disclaimers
*Finite element analysis indicated that the addition of 2 mm of tendinous tissue on the bursal side of a supraspinatus tendon with an articular-sided tear reduced the peak strain at the site of the tear by 40%.
**On human biopsy (n=1) and in-vivo sampling.
***Patients with partial thickness tears; 3 to 12 months n=46, 2 year n=13, 5 years n=11.
****Demonstrated in a study of patients with partial-thickness tears.
*****Demonstrated in patients with partial and full-thickness tears, compared to pre-operative values; p≤0.015.
Citations
1. Van Kampen C, Arnoczky S, Parks P, et al. Tissue-engineered augmentation of a rotator cuff tendon using a reconstituted collagen scaffold: a histological evaluation in sheep. Muscles Ligaments Tendons J. 2013;3(3):229-235. Published 2013 Aug 11.
2. Arnoczky SP, Bishai SK, Schofield B, et al. Histologic Evaluation of Biopsy Specimens Obtained After Rotator Cuff Repair Augmented With a Highly Porous Collagen Implant. Arthroscopy. 2017;33(2):278-283. doi:10.1016/j.arthro.2016.06.047
3. Smith+Nephew 2020 REGENETEN Collagen Implant Physical Characteristics. Internal Report Internal Report. 15009769
4. Camacho-Chacon JA, Cuenca-Espierrez J, Roda-Rojo V, et al. Bioinductive collagen implants facilitate tendon regeneration in rotator cuff tears. J Exp Orthop. 2022;9(1):53. Published 2022 Jun 8. doi:10.1186/s40634-022-00495-7
5. Camacho Chacón JA, Roda Rojo V, Martin Martinez A, et al. An isolated bioinductive repair vs sutured repair for full-thickness rotator cuff tears: 2-year results of a double blinded, randomized controlled trial. J Shoulder Elbow Surg. 2024;33(9):1894-1904. doi:10.1016/j.jse.2024.03.043
6. Bokor DJ, Sonnabend D, Deady L, et al. Evidence of healing of partial-thickness rotator cuff tears following arthroscopic augmentation with a collagen implant: a 2-year MRI follow-up. Muscles Ligaments Tendons J. 2016;6(1):16-25. Published 2016 May 19. doi:10.11138/mltj/2016.6.1.016
7. Schlegel TF, Abrams JS, Angelo RL, Getelman MH, Ho CP, Bushnell BD. Isolated bioinductive repair of partial-thickness rotator cuff tears using a resorbable bovine collagen implant: two-year radiologic and clinical outcomes from a prospective multicenter study. J Shoulder Elbow Surg. 2021;30(8):1938-1948. doi:10.1016/j.jse.2020.10.022
8. Bushnell BD, Bishai SK, Krupp RJ, et al. Treatment of Partial-Thickness Rotator Cuff Tears With a Resorbable Bioinductive Bovine Collagen Implant: 1-Year Results From a Prospective Multicenter Registry. Orthop J Sports Med. 2021;9(8):23259671211027850. Published 2021 Aug 13. doi:10.1177/23259671211027850
9. Ruiz Ibán MÁ, García Navlet M, Moros Marco S, et al. Augmentation of a Transosseous-Equivalent Repair in Posterosuperior Nonacute Rotator Cuff Tears With a Bioinductive Collagen Implant Decreases the Retear Rate at 1 Year: A Randomized Controlled Trial. Arthroscopy. 2024;40(6):1760-1773. doi:10.1016/j.arthro.2023.12.014
10. Schlegel TF, et al. J Shoulder Elbow Surg. 2018.
11. Warren JR, Domingo-Johnson ER, Sorensen AA, Cheng AL, Latz KH, Cil A. Bioinductive patch as an augmentation for rotator cuff repair, a systematic review and meta-analysis. J Shoulder Elbow Surg. 2024;33(11):2515-2529. doi:10.1016/j.jse.2024.05.002