‡ In these countries please contact our distributor

PICO sNPWT Cardio Evidence

Combat the repercussions

Evidence supports PICO sNPWT in helping reduce wound complications and costs associated with cardiac surgery*1-3 

The consequences of surgical site complications (SSCs) following coronary artery bypass graft surgery (CABG) can be devastating. The spread of a superficial infection to the deep tissue is of particular concern, with deep sternal wound infections (DSWI) resulting in an in-hospital mortality rate of up to 35%4. Furthermore, a length of stay as long as 23 days per patient5 incurs substantial associated healthcare costs5.

10.8% surgical site infection (SSI) rate for cardiac surgery.5


23-day median additional length of stay following SSI.5


£11,003 median additional cost following SSI.5


Potential to improve outcomes and efficiencies…particularly for high-risk patients*

A growing body of evidence suggests that prophylactic use of  PICO sNPWT may help*...

…reduce SSCs, which may lead to a reduction in DWSIs by helping prevent the spread of superficial infectious material


Read summary


70% relative reduction in SSCs following coronary artery bypass grafting surgery (CABG)***2


 Read summary

86% relative reduction in superficial SSIs following CABG surgery.***2 


 …reduce per-patient treatment costs and length of stay

Shown to save an estimated €1,295 per patient in a study, releasing capacity to treat 10 additional patients.**1


Highlighting the importance of SSC prevention, a study showed that patients with SSCs may spend ~10 days longer in hospital, irrespective of treatment choice. **1

Get the experts’ experience of using PICO sNPWT


…make a difference for high-risk patients

Guidance from the UK’s NICE supports the use of PICO sNPWT to help prevent SSCs in high-risk patients with closed surgical incisions, at a similar overall cost.*6

Compared to standard care:

63% reduction in the overall risk of SSI.7


30% reduction in the risk of dehiscence.7 


77% reduction in the risk of seroma.


1.75-day length of stay reduction across surgical specialties, used prophylactically.7



How does PICO Therapy work?

Only PICO sNPWT dressings have proprietary AIRLOCK™ Technology for uniform, consistent delivery of therapeutic NPWT across a closed surgical incision and the surrounding zone of injury.8-11

Find out more about PICO Therapy


How to apply PICO sNPWT



Is your patient high-risk?

Identifying high-risk patients is fundamental to preventing major infection following sternotomy.12 


For further information or guidance, please contact us.


Helping you get CLOSER TO ZERO surgical site complications.13 


*compared to conventional dressings/standard care

**Review of anonymised records before and after the introduction of PICO sNPWT for high-risk patients (≥2 SSI risk factors) undergoing cardiac surgery in a hospital in France. 142 patients received PICO sNPWT vs 91 receiving standard care. Mean age: 65-67 years respectively). Reduction in SSCs: 6.3% vs 17.6%. p=0.009. Reduction in mediastinitis: 3.5% vs 11.0%. p=0.029.

***Open label, prospective study of patients with closed sternotomy wounds, treated with either PICO sNPWT (n=40) or conventional dressings (n=40). Mean age: 62 vs 66 years respectively. SSC reduction: PICO sNPWT group 7.5% (n=3) vs conventional dressings 25.0% (n=10). p=0.034. Superficial SSI reduction: PICO sNPWT group 2.5% (n=1) vs conventional dressings 17.5% (n=7). p=0.025. Antibiotics use: p=0.043.




1. Tabley A, Aludaat C, Le Guillou V, et al. A survey of cardiac surgery infections with PICO Negative Pressure Therapy in high-risk patients: survey of surgical site complications. Ann Thorac Surg. 2020 [Epub ahead of print] Available at: Annals of Thoracic Surgery.
2. Witt-Majchrzak A, Żelazny P, Snarska J. Preliminary outcome of treatment of postoperative primarily closed sternotomy wounds treated using negative pressure wound therapy. Pol Przegl Chir. 2015;86(10):456-465. Available at: Polski Przeglad Chirurgiczny
3. Nherera LM, Trueman P, Schmoeckel M, Fatoye FA. Cost-effectiveness analysis of single use negative pressure wound therapy dressings (sNPWT) compared to standard of care in reducing surgical site complications (SSC) in patients undergoing coronary artery bypass grafting surgery. J Cardiothorac Surg. 2018;13:103. Available at: Journal of Cardiothoracic Surgery.
4. Cotogni P, Barbero C, Rinaldi M. Deep sternal wound infection after cardiac surgery: Evidences and controversies World J Crit Care Med 2015;4(4): 265- 273.
5. Jenks, P.J., Laurent, M., McQuarry, S. and Watkins, R., 2014. Clinical and economic burden of surgical site infection (SSI) and predicted financial consequences of elimination of SSI from an English hospital. Journal of Hospital Infection, 86(1), pp.24-33.
6. NICE (2019) PICO negative pressure wound dressings for closed surgical incisions [online] accessible from:
7. Saunders, C., Buzza, K. and Nherera, L. 2019. A single use negative pressure system reduces surgical site complications compared with conventional dressings in closed surgical incisions: a systematic literature review with meta- analysis. Poster presented at the European Wound Management Association annual meeting, June 5-7, 2019, Gothenburg, Sweden.
8. Data on file reference 1102010 – Bacterial Barrier Testing (wet-wet) of PICO Dressing with a 7 day Test Duration against S. marcescens.
9. Malmsjo, M., Huddleston, E. and Martin, R., 2014. Biological effects of a disposable, canisterless negative pressure wound therapy system. Eplasty. 
10. Pellino, G., Sciaudone, G., Candilio, G., Campitiello, F., Selvaggi, F. and Canonico, S., 2014. Effects of a new pocket device for negative pressure wound therapy on surgical wounds of patients affected with Crohn’s disease: a pilot trial. Surgical innovation, 21(2), pp.204-212.
11. Hudson, D.A., Adams, K.G., Van Huyssteen, A., Martin, R. and Huddleston, E.M., 2015. Simplified negative pressure wound therapy: clinical evaluation of an ultraportable, no‐canister system. International wound journal, 12(2), pp.195-201.
12. Fowler Jr, V.G., O’Brien, S.M., Muhlbaier, L.H., Corey, G.R., Ferguson, T.B. and Peterson, E.D., 2005. Clinical predictors of major infections after cardiac surgery. Circulation, 112(9_supplement), pp.I-358.
13. Smith+Nephew. April 2019. Outcomes following PICO compared to conventional dressings when used prophylactically on closed surgical incisions: systematic literature review and meta-analysis. Report reference EO/AWM/PICO/004/v3.

NICE recognition for PICO

Read the NICE guidelines, recommending the adoption of PICO sNPWT
to help reduce surgical site complications in high-risk patients.

Read the guidelines

Contact us about RENASYS

Request a demo