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Resistance and Safety

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Iodosorb Cadexomer Matrix with Iodine


Iodine Resistance

There is no known resistance of organisms to Iodine, which is a common problem with many bactericides. In addition to this Iodine has viricidal, fungicidal and amoebicidal properties that most other antiseptics do not possess. 3


Iodine Toxicity

If Iodine is presented at a high concentration (>1% free) it can be toxic to newly formed tissue within a wound e.g. fibroblasts 2. However, Iodosorb* has a concentration of 0.9% Cadexomer Iodine and studies have shown that at this concentration and complexed to cadexomer, there is no evidence that Iodosorb is toxic. Moreover, the concentration gradient of iodine is formed with the lowest concentration of iodine at the wound surface and the greatest concentration away from the wound 1. This slow release property and iodine concentration gradient have been thought to allow a non-toxic concentration of iodine to be maintained at the wound surface.

Cadexomer is a high molecular weight compound and will not be directly absorbed after application to wounds. It is, however, biologically degraded. As the Iodine is physically immobilised and not chemically complexed within the cadexomer particles it is easily released and is absorbed through damaged skin. Although a small amount may be metabolised, the amount of Iodine absorbed under clinical conditions is small and within acceptable physiological levels 1, if the product is used within the specified dosing regime.