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Iodosorb* Abstract 4

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Iodosorb Cadexomer Matrix with Iodine

 

Controlled Trial of Iodosorb in Chronic Venous Ulcers.


M.C. Ormiston, M.T. Seymour, G.E Venn, R.I. Cohen, J.A.Fox


British Medical Journal (1985) Vol 291; 308-310

 

Abstract

Cadexomer iodine ( Iodosorb) is a hydrophilic starch powder containing iodine, which is suitable for dressing granulating wounds such as venous ulcers. A total of 61 outpatients with chronic venous ulcers participated in a randomised optional crossover trial using cadexomer iodine or a standard dressing for their ulcers. The trial lasted 24 weeks or until the ulcer had healed. Two patients withdrew during the course of the trial. Both treatments were highly effective, but the epithelium of ulcers dressed with cadexomer iodine grew significantly faster (p < 0.001). At the midpoint of the trial (12th week) 13 of the 30 patients receiving standard treatment were changed to cadexomer iodine, while only three of 29 receiving cadexomer iodine changed to the standard dressing (p < 0.02). In most cases ulcers were dressed and rebandaged daily by the patients themselves after instruction and supervision. This may be better than having dressings and bandages applied by professionals less regularly.