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Iodosorb* Abstract 13

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Iodosorb Cadexomer Matrix with Iodine


Can Antimicrobials be Effective Without Impairing Wound Healing? The Evaluation of a Cadexomer Iodine Ointment

P.M. Mertz, S.C. Davis, L.D. Brewer, L.Franzen.

Wounds (1994) 6 (6) 184-193



The use of povidone iodine is not recommended for open wound treatment. It has been shown to be toxic to skin cells in vitro and to have a limited antimicrobial effect in vivo. The purpose of the studies was to evaluate the efficacy of a cadexomer iodine ointment on wound epithelisation and infection. Partial thickness wounds were made on the backs of 12 pigs. Six animals were used for the epithelisation assessment, three for the antimicrobial study and three for the histologic analysis. The wounds were divided into three treatment groups: 1) untreated control, 2) cadexomer iodine ointment, and 3) ointment base.


The results from the epithelisation study showed that on day five post wounding, cadexomer iodine ointment treated wounds were 48.5% epithelialised as compared to air exposed and vehicle which were both 23% epithelised (p < 0.05). The Healing Time and histological comparison of data showed no differences in epithelisation rates. The microbiology study showed that at the 24, 48 and 72 hour time points, there were significantly fewer numbers of S. aureus recovered from cadexomer iodine ointment treated wounds as compared to both ointment base and untreated control wounds (p < 0.03). No differences in bacterial counts were observed with ointment based treated wounds and untreated control wounds. In wounds inoculated with Ps. aeruginosa, cadexomer iodine ointment only reduced the bacterial count at 48 hours when compared to air exposed, but not ointment base.