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Iodosorb* Evidence

This information is intended for Healthcare Professionals only.

 

Expert Statement

 

Vincent Falanga, MD
Professor of Dermatology and Biochemistry


"The development of slow-release antiseptic agents, such as those based on iodine, has rendered antiseptics safe, effective, and reliable in the management of difficult wounds. In my own practice, I have found these therapeutic agents particularly useful in the bacterial "de-colonization" of chronic wounds, an important step in the overall approach to wound bed

Vincent Falanga, MD

preparation. As a result, patient management is greatly facilitated, whether one is simply applying standard treatments or using more advanced therapies. The bacterial burden decreases, as does wound exudate. Quite frankly, I don't know what I would do without the use of slow-release antiseptics, particularly in the outpatient setting. I do know that some of my clinician colleagues are still fearful of the word "antiseptics". This fear is rooted in old literature on the use of "straight" antiseptics, with no mechanisms for slow and smart delivery. However, in the field of medicine and in caring for patients, one needs to adapt while remaining critical, and most of all be vigilant about new opportunities that can help our patients."

 

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Clinical Evidence

 

The table below details numerous clinical papers and case studies on the use of Iodosorb in different indications.

 

Click on the links to access the abstracts and animations

 

Wound Type Indication Author and Journal Title Abstract

•Ischaemic

Ulcers
•Pressure

Ulcers
•Diabetic

& Venous

Ulcers
•Summary

Effective on wounds containing non viable tissue with bacterial burden

 

 

Dr Gordon Dow presents on the use of Iodosorb in various aetiologies

Case Studies

 

 

Abstract 1>

 

 

Chronic wounds

 

 

Lack of cytotoxicity

 

 

L.H Zhou, et al
British Journal of Dermatology.

 

 

Slow release iodine preparation and wound healing: In vitro effects consistent with lack of in vivo toxicity in human chronic wounds

Abstract 2>

 

 

Effective use on sloughy, infected (dirty) wounds J.Sundberg, R.Meller
Wounds (1997) 9 (3) 68-86
A Retrospective Review of the Use of Cadexomer Iodine in the Treatment of Chronic Wounds Abstract 3>

Venous Leg Ulcers

Sustained Antimicrobial release

M.C. Ormiston, et al British Medical Journal (1985) Vol 291; 308-310

Controlled Trial of Iodosorb in Chronic Venous Ulcers.

Abstract 4>

 

Slough removal and wound cleansing.
Good absorption capacity.

E.Skog, et al
British Journal of Dermatology (1983) 109; 77-83.

A Randomised Trial comparing Cadexomer Iodine and Standard Treatment in the Out- Patient Management of Chronic Venous Ulcers.

Abstract 5>

Effective removal of slough and debris

L. Hillstrom

Acta Chir Scand Suppl 544: 53-56 - 1988

Iodosorb Compared to Standard Treatment in Chronic Venous Leg Ulcers - A Multi Centre Study. Abstract 6>
Safe use of Iodine C.Floyer, J.D. Wilkinson.
Acta Chir Scand Suppl 544: 60-61 1988
Treatment of Venous Leg Ulcers with Cadexomer Iodine with Particular Reference to Iodine Sensitivity Abstract 7>
Diabetic Foot Ulcers Cost Effectiveness J. Apelqvist, G. Ragnarson Tennvall
Acta Derm Veneraol (Stockh) (1996) 76: 231-235
Cavity Foot Ulcers in Diabetic Patients: A Comparative Study of Cadexomer Iodine Ointment and Standard Treatment. Abstract 8>
Management of exudate and bioburden M Marazzi, MD et al. Tissue Therapy Dept., Plastic Surgery & Burn Centre, Niguarda Hospital Milan (Italy) Case study 1 - Female, 39 years old, with diabetic ulcer in her right foot for 2 years. Abstract 9>
Management of exudate and bioburden M Marazzi, MD et al. Tissue Therapy Dept., Plastic Surgery & Burn Centre, Niguarda Hospital Milan (Italy) Case study 2 - Male, 65 years old, with diabetic ulcers of the right foot. Abstract 10>
Management of exudate and bioburden M Marazzi, MD et al. Tissue Therapy Dept., Plastic Surgery & Burn Centre, Niguarda Hospital Milan (Italy)

Case study 3 - Male, 66 years old, with diabetic ulcer (right foot) for 2 months

Abstract 11>
General Additional healing properties Tomoyuki Ohtami et al. Exp Dermatol 2007 Apr;16(4):318-23 Cadexomer as well as cadexomer iodine induces the production of proinflammatory cytokines and vascular endothelial growth factor by human macrophages Abstract 12>
Animal model Sustained antimicrobial effect P.M. Mertz, S.C. Davis, L.D. Brewer, L.Franzen.
Wounds (1994) 6 (6) 184-193
Can Antimicrobials be Effective Without Impairing Wound Healing? The Evaluation of a Cadexomer Iodine Ointment Abstract 13>

 

 

 

Glossary

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References

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