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Abstract - Can Antimicrobials be Effective Without Impairing Wound Healing? The Evaluation of a Cadexomer Iodine Ointment

P.M. Mertz, S.C. Davis, L.D. Brewer, L.Franzen.
Wounds (1994) 6 (6) 184-193

Can Antimicrobials be Effective Without Impairing Wound Healing? The Evaluation of a Cadexomer Iodine Ointment

Clinical Paper Abstract

The use of povidone iodine is not recommended for open wound treatment. It has been shown to be toxic to skin cells in vitro and to have a limited antimicrobial effect in vivo. The purpose of the studies was to evaluate the efficacy of a cadexomer iodine ointment on wound epithelisation and infection. Partial thickness wounds were made on the backs of 12 pigs. Six animals were used for the epithelisation assessment, three for the antimicrobial study and three for the histologic analysis. The wounds were divided into three treatment groups: 1) untreated control, 2) cadexomer iodine ointment, and 3) ointment base.

The results from the epithelisation study showed that on day five post wounding, cadexomer iodine ointment treated wounds were 48.5% epithelialised as compared to air exposed and vehicle which were both 23% epithelised (p < 0.05). The Healing Time and histological comparison of data showed no differences in epithelisation rates. The microbiology study showed that at the 24, 48 and 72 hour time points, there were significantly fewer numbers of S. aureus recovered from cadexomer iodine ointment treated wounds as compared to both ointment base and untreated control wounds (p < 0.03). No differences in bacterial counts were observed with ointment based treated wounds and untreated control wounds. In wounds inoculated with Ps. aeruginosa, cadexomer iodine ointment only reduced the bacterial count at 48 hours when compared to air exposed, but not ointment base.

The histology study showed wounds treated with the cadexomer iodine had an increase in epithelisation and white cell infiltrate as compared to ointment base. These studies confirm that unlike conventional povidone iodine, the cadexomer iodine was not only able to accelerate the rate of epidermal migration in partial thickness wounds, but also able to reduce the number of pathogens.

Slough Removal Antibacterial Efficacy Sustained Antibacterial effect Exudate Management Effective Wound Healing Odour Patient Comfort Cost/Time Savings Sensitivity
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