New "The Lancet" publication backs incisional NPWT

Discover an up-to-date meta-analysis and trial sequential analysis (TSA) results that has been done by an independent external peer review, to provide an overview of the efficacy of Negative Pressure Wound Therapy (NPWT) vs standard dressings on the incidence of Surgical Site Infection (SSI) where 57 RCTs with 13 744 patients has been included. 


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Evidence in focus: Incisional negative pressure wound therapy for the prevention of surgical site infection: an up-to date meta-analysis and trial sequential analysis.

Groenen H, Jalalzadeh H, Buis DR, et al. eClinicalMedicine (part of the Lancet group). 2023;62;102105

 

+ Overview

 

  • Previously conducted meta-analyses and RCTs for NPWT prevention of SSI are contradictory
  • Implementation of NPWT is impaired due to inconsistent recommendations by international guidelines
  • This study compared NPWT with standard dressings on closed incisional wounds in adult patients undergoing any type of surgery
  • Providing an up-to date systematic review and meta-analysis
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+ Methodology  

+ Results

+ Conclusion

 

This meta-analysis confidently showed that single use iNPWT reduces SSI irrespective of surgical specialty, whilst trial sequential analysis demonstrated the robustness of this evidence. Additionally, no significant differences were observed between -80mmHg and -125mmHg devices.

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+ Our engagement

We are dedicated to supporting healthcare professionals in reducing the human and economic impacts of post-operative surgical site complications (SSCs).

The development of SSCs, such as surgical site infections (SSIs), oedema, seroma,  haemotoma, or surgical wound dehiscence is a substantial burden for patients and healthcare systems globally.1

Discover how we are shaping what's possible in reducing the burden of surgical wound complications

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Citations
1. Groenen H, et al. The Lancet Journal. Volume 62, August 2023, p1-14.
2. Gillespie BM et al. Worldwide incidence of surgical site infections in general surgical patients: A systematic review and meta-analysis of 488,594 patients. Int J Surg. 2021 Nov;95:106136. doi: 10.1016/j.ijsu.2021.106136. Epub 2021 Oct 13. PMID: 34655800.

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