‡ In these countries please contact our distributor

Collagenase SANTYL

Ointment 250 units/gram


Collagenase SANTYL Ointment is the only enzymatic debrider approved by the FDA for use in the U.S. It selectively removes necrotic tissue without harming granulation tissue.

Collagenase SANTYL Ointment is indicated for debriding chronic dermal ulcers and severely burned areas.

Occasional slight transient erythema has been noted in surrounding tissue when applied outside the wound. One case of systemic hypersensitivity has been reported after 1 year of treatment with collagenase and cortisone. Use of Collagenase SANTYL Ointment should be terminated when debridement is complete and granulation tissue is well established.

Adobe Acrobat PDF icon For complete prescribing information please click here (PDF 0.5MB)

This information is intended for health care professionals only.

*The decision to use Smith+Nephew products should be made by a healthcare professional, in line with applicable local protocols.  Smith+Nephew products should always be used for the indications set out in the applicable instructions for use.

United States healthcare professionals only

Learn more about SANTYL products in the US


US and Canada only

Collagenase SANTYL Ointment 250 units/gram is only approved for use in the United States and Canada.