CARTIHEAL◊ AGILI-C◊ Cartilage Repair Implant

Bringing you the latest clinical evidence, technique tips, events and updates for a new standard of knee cartilage repair. Save this page to your favorites and stay tuned for more news coming soon.
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Latest news

Check out the latest breakthroughs, announcements and highlights for the CARTIHEAL Implant to stay ahead of the conversation.

Clinical evidence

Find out why clinical evidence continues to support the CARTIHEAL Implant with our latest blogs and data summaries.

Surgical techniques

Get technique tips, pearls and guidance on how to use the CARTIHEAL Implant in surgeon videos and animations.

Expert insights and case studies

Listen to real-world experiences with the CARTIHEAL Implant to find out why it's transforming surgeon practices and patient outcomes.

Upcoming tradeshows

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Podcasts

Tune in to hear what your peers are saying about knee cartilage repair.

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Continued learning

Advantages of using the CARTIHEAL Implant

  • Can be used to repair cartilage, restore bone and relieve pain1-4
  • Simple, single-stage surgical procedure with no donor tissue required.
  • A proprietary biomaterial that is porous and biocompatible.
  • Clinically meaningful improvements in pain, function and quality of life, demonstrated in an RCT.*1,2
  • Twice the pain reduction versus microfracture or debridement, demonstrated in an RCT.*1,2
  • 87% reduction in the relative risk of total knee arthroplasty or osteotomy, demonstrated in an RCT.**2
  • Significant improvements in patient-reported outcome measures (KOOS, IKDC), with superior results when compared to the surgical standard of care.***1,2
  • Helps the body repair knee cartilage and restore damaged bone,1-4 and shown to be largely resorbed by the body within 18 months.1,4,5
  • The only device approved for the treatment of knee cartilage and osteochondral defects in patients with or without mild to moderate osteoarthritis (KL 0-3).****6
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Disclaimers

*At 2- and 4-year follow-up.

**Compared to the surgical standard of care (microfracture or debridement) at 4-year follow-up.

***Over 2 and 4 yr follow-up; standard of care = microfracture or debridement.

****Information accurate at the time of writing, January 2026.

Products may not be available in all markets because product availability is subject to the regulatory and/or medical practices in individual markets. Please contact your Smith+Nephew representative or distributor if you have questions about the availability of Smith+Nephew products in your area. For detailed product information, including indications for use, contraindications, precautions and warnings, please consult the product’s applicable Instructions for Use (IFU) prior to use.

Citations
  1. Altschuler, et al. AJSM 2023: 51(4), 957-967
  2. Conte P, et al. Int Orthop. 2024;48(12):3117–3126.
  3. Kon E, et al. J Orthop Surg Res. 2015 May 28;10:81.
  4. Kon E, et al. Am J Sports Med. 2021 Mar;49(3):588-598.
  5. Kon E, et al. Injury. 2016;47 Suppl 6:S27-S32.
  6. CartiHeal 2009. Indications for Use: Agili-C implant.

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