The ACTICOAT difference

As a clinician you want to remove the pain, the odour and the swelling as fast as possible and get your patient and their wound back on track to healing.

In a sea of antimicrobial choices including many different silvers alongside alternative antimicrobial therapies such as PHMB, honey, DACC or iodine it can be difficult to decide what is best for your patients.

ACTICOAT is different. It has been shown in clinical trials to improve patient outcomes within 2 weeks8.

In a comparative study in mixed chronic wounds (n=75) comparing 3 different silver dressings ACTICOAT was found to be more effective than either other dressing in time to resolve clinical signs of local infection (p<0.05) and time to wound healing (p<0.05). Clinical signs of infection were resolved within 2 weeks in 60% of cases dressed with ACTICOAT compared to 8% or 4% of patients in the other silver dressing groups (Fig. 1). Patients using ACTICOAT were nearly 3 times more likely to heal at any time during the study versus patients in the other treatment groups8.

ACTICOAT antimicrobial dressings compared to other silver dressings

Figure 1. In a comparative study in mixed chronic wounds (n=75) clinical signs of infection were resolved within 2 weeks in 60% of cases dressed with ACTICOAT compared to 8% or 4% of patients in the other silver dressing groups8

As well as being proven on patients ACTICOAT has demonstrated its efficacy against high risk microbes in the laboratory.

ACTICOAT variants have been shown to be bacteriacidal against antibiotic resistant superbugs such as MRSA‡, VRE‡9,10,11 and NDM-1 Carbapenemases†12 within 30 minutes (in-vitro)9,10,11,12. Its unique nanocrystalline silver structure enables optimal antimicrobial activity that is sustained for the wear time of the dressing10,11,13,14.

Change the outcome, take the ACTICOAT 2 WEEK CHALLENGE.

Apply to receive a 2 week's supply of ACTICOAT Flex* samples for appropriate use on an infected wound.


*Where possible samples will be ACTICOAT Flex, in areas where ACTICOAT Flex is not registered an alternative ACTICOAT variant may be offered.

™ All trademarks acknowledged


  1. Kelly J. Addressing the problem of increased antibiotic resistance. Prof Nurs 2001; 17(1): 56-9
  2. Hamilton-Miller JMT, Shah S, Smith C. Silver sulphadiazine: a comprehensive in-vitro reassessment. Chemotherapy 1993; 39: 405-9
  3. Maillard J-Y and Denyer SP. 2006. Focus on Silver. EWMA JournalV6(1)
  4. Warriner R and Burrell R. Infection and the chronic wound - a focus on silver. Advances in Skin and Wound Care Vol 18 (Supp. 1) Oct 2005
  5. Chopra I. (2007) The increasing use of silver based products as antimicrobial agents: a useful development or a cause of concern. Journal of Antimicrobial Chemotherapy 59, 587-590
  6. Vlachou E, et al. The safety of nanocrystalline silver dressings on burns: A study of systemic absorption. Burns 2007. 33(8):979-85
  7. Sibbald R G, Browne A C, Coutts P, Queen D, 'A Screening Evaluation of an Ionized Nanocrystalline Silver Dressing in Chronic Wound Care'. Ostomy Wound Management 2001; 47(10): 38-4
  8. Gago M, et al., A comparison of three silver-containing dressings in the treatment of infected, chronic wounds. Wounds 2008; 20 (10): 273-278
  9. Wright JB, et al. 'Wound Management in an era of increasing bacterial antibiotic resistance: A role for topical silver treatment', American Journal of Infection Control 1998; 26(6): 572-577 
  10. Smith & Nephew Data on File; 0810016 
  11. Smith & Nephew Data on File; 0810017 
  12. Hope R, et al., (2012) The in-vitro antibacterial activity of nanocrystalline silver dressings against bacteria withNDM-1 carbapenemase. Poster at EWMA, Austria, 2012. 
  13. Smith & Nephew Data on File WRP-TW141-022 
  14. Westain Report Ref: #971030
  15. World Union of Wound Healing Societies (WUWHS). Principles of best practice: Wound infection in clinical practice. An international consensus. London: MEP Ltd, 2008. Available from  
  16. International consensus. Appropriate use of silver dressings in wounds. An expert working group consensus. London: Wounds International, 2012.Available 
  17. Searle and Bielby (2010) Dressing strategies for the management of infected wounds in community wound care: impacts and implications. Poster at Wounds UK, Harrogate Nov 2010.
  18. Murray, S and Pardoe, A (2010) Making an Impact: Improving the patient experience using ACTICOAT Flex. Case Study Booklet 
  19. Tongue G., Prytherch J., Harvey A. The Silver Revolution. Exeter Primary Care Trust. Poster Presentation. Wounds UK. Harrogate 2004 
  20. Bowering K. “ACTICOAT Moisture Control. A New Clinical Option” Case study presentation. Satellite Symposium at Stuttgart (a joint meeting for ETRS, EWMA and DGfW) 2005

Infected Wounds

the outcome