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IntraSite* Product Range

Product Range

Wound Bed Preparation


IntraSite Gel

The unique APPLIPAK is a mushroom shaped device containing IntraSite Gel that is available in a range of different sizes. It provides directable and controlled application of the gel.

Detailed Product Information



IntraSite Conformable

Combines the advantages of the gel with a non-woven dressing to aid the gentle packing of deep, shallow or open undermined wounds ensuring the gel remains in close contact with the entire wound surface.

Detailed Product Information

  INTRASITE Conformable


IntraSite Gel is low adherent so is easily removed from the wound by irrigating with normal saline, without harming fragile tissue or causing unnecessary pain for the patient.


Balanced Formulation

IntraSite* Gel is an amorphous hydrogel that promotes gentle but effective debridement and desloughing. IntraSite Gel has unique chemical characteristics unlike any other hydrogel.


Unique Formulation



The patented cross-linked polymer enables the gel to provide balanced rehydration and absorption. Based on the local environment IntraSite Gel responds appropriately to the level of moisture making it ideal for every stage in the wound healing process.


Unique cross linked molecular structure



The unique structure provides the ability to balance re-hydration and absorption as required.

  • Water is donated from the gel to the wound
  • Slough and exudates are absorbed from the wound into the gel


Cross linked stability



Cross linking holds the gel stable throughout treatment, avoiding leakage and drainage.

  • As slough and exudates are absorbed from the wound, the links expand their original state.
  • As water is donated, the links contract.


Versatile Presentations


IntraSite Gel comes in two forms, a gel filled Applipak* and an impregnated non-woven dressing for use in different clinical situations. The gel is odourless and has a slightly opaque, colourless appearance.






This information is intended for Healthcare Professionals only.


Wound Bed Preparation


Wound dressings that maintain a moist wound bed can provide an optimal environment for debridement as they allow the phagocytic cells to liquefy necrotic tissue thereby promoting granulation. Autolytic debridement is easy to perform and does not damage healthy tissue surrounding the wound. Furthermore, the pain experienced by the patient when using this method is minimal. As autolytic debridement occurs naturally, the process requires limited technical skill.


Intrasite* Gel has been clinically proven to debride and deslough wounds with a gentle action that prepares the wound bed to provide the optimum environment for rapid wound healing.



Click on the pictures below to view the animation.



Click to view Necrotic animation


  • Gently and effectively rehydrates and debrides necrotic tissue.
  • Promotes natural autolytic process.
  • Promotes desloughing and absorption of excess exudates, bacteria and toxins.
  • Effective as a debriding agent in burns.

Click to view Sloughy animation


  • Gently and effectively rehydrates and absorbs sloughy tissue.
  • Maintains integrity of fragile granulating tissue
  • Promotes rapid proteolysis.



Click to view Granulating animation
  • Encourages fast, trouble-free moist wound healing.
  • Fragile granulating tissue is kept moist.
  • Minimises wound management time





Click to view Epithelialising animation


  • Non-aggressive action leaves granulating tissue undisturbed.
  • Allows migration of epithelialising cells.
  • Low adherent - reduces patient trauma during dressing changes.



IntraSite Gel & Wound Bed Preparation


The aim of Wound Bed Preparation is to create an optimal wound healing environment in order to obtain maximum benefits from today's advanced wound care products. IntraSite Gel and Conformable are crucial products within the concept of Wound Bed Preparation as they can be used on chronic wounds owing to their re-hydration and absorption properties. Their rehydration properties are of particular importance for hard necrotic wounds in preparing the wound bed.



This information is intended for Healthcare Professionals only.





IntraSite* Gel & Conformable Case Studies


Read about actual experiences that clinicians and patients have had with IntraSite Gel and Conformable as well as seeing photographic evidence of the result



Bacteriostatic properties of IntraSite Gel vs. Purilon^ Gel

 IntraSite Gel has been compared in-vitro against another hydrogel product. The results showed that IntraSite Gel, in contrast to the other product, had bacteriostatic and fungistatic activity against three common wound pathogens


Compatibility of IntraSite Gel with Acticoat*

IntraSite Gel and Acticoat* are compatible with each other. Evidence suggests that IntraSite Gel can aid sustainable moistening of Acticoat.


^Purilon Gel is a registered Trade Mark of Coloplast A/S


This information is intended for Healthcare Professionals only.



Colin, D., Kurring, R.G.N., Quinlan, D., Yvon, C. Managing Sloughy Pressure Sores. J Wound Care 1996; 5: 10.

This Clinical Investigation compares the performance of an amorphous hydrogel and a dextranomer paste in the management of sloughy pressure sores in the hospital environment. Specific parameters measured during the study were efficacy, safety, ease of handling and patient comfort. The clinical investigation was restricted to the debridement of sloughy non-viable tissue only. The amorphous hydrogel and dextranomer paste performed to a similar standard in terms of debridement of non-viable tissue. At day 21, however, the median reduction in wound area was 35% in the amorphous hydrogel group compared with 7% in the dextranomer paste group.



Vernon, T. IntraSite Gel and IntraSite Conformable: The Hydrogel Range. British Journal of Community Nursing 2000; 5: 10: 511-516

Wound management can be a confusing area of nursing practice. Even when an holistic patient assessment has been undertaken healthcare professionals frequently ask for guidance when faced with choosing the most appropriate wound management product. This article reviews two hydrogels from Smith & Nephew Healthcare - IntraSite Gel and IntraSite Conformable, which is the latest addition to the hydrogel range.




Punder, R. Amorphous Hydrogel Dressings in Wound Management. Journal of Community Nursing 2001; 15: 6:43-46
This is the third in a series of articles examining the role of a variety of wound care products used in clinical practice. This article will examine the use of amorphous hydrogels that are widely used in practice to debride necrotic and sloughy wounds, and discuss some of the research that has been undertaken in this area. The hydrogel dressings fulfil many of the characteristics of an ideal dressing as they provide a moist environment, are non-adherent and can be removed from the wound without causing trauma, are safe to use, free from particulate contaminants and are available in the hospital and community settings




Jones, V. Use of Hydrogels and Iodine in Diabetic Foot Lesions. The Diabetic Foot 1999; 2: 2:47-48
Although not usually the first dressing of choice for a diabetic foot ulcer, both hydrogels and iodine-based dressing materials may, on occasions, provide useful alternatives for practitioners. Improved formulations of hydrogels and advances in our knowledge of the effects of iodine have extended the application of these dressings to cover a wider range of wound problems affecting the diabetic foot.




Ratcliff, C, R. IntraSite Gel to Promote Wound Healing from Necrosis. The Cancer Bulletin 1991; 43: 1:85-86
Localised carcinomas of the cervix are usually responsive to radiotherapy. Those that are not are considered secondary to the bulk of the tumour at the beginning of radiotherapy. In an attempt to reduce the tumour volume intra-arterial chemotherapy, which delivers large concentrations of chemotherapeutic agents through the arteries supplying the malignant area, may be given prior to radiotherapy to patients with advanced localised disease. Necrosis is occasionally seen as a complication of the intra-arterial therapy or the radiotherapy and presents a challenge in terms of clinical management of the wound. The use of a hydrogel to promote healing in such a case is reviewed in this article




Fry, M, M. A Framework for Wound Management. Nursing Standard 1993; 7: 28:29-32
This article looks into four of effectively the most commonly used wound dressing products: IntraSite, Kaltostat, Lyofoam and Granuflex. Their characteristics and uses are discussed, and a simple framework for choosing the appropriate dressing for individual wounds has been complied. The author concludes that there is no 'ideal' dressing which can be used at all the stages of the wound healing process.




Bale, S., Banks, V., Harding, K,G. A Comparison of Two Amorphous Hydrogels in the Debridement of Pressure Sores. Journal of Wound Care 1998; 7: 2:65-68
This study compared the efficiency of two hydrogel dressings in the debridement of necrotic pressure sores. This randomised, controlled, assessor-blind, clinical trial involved 50 patients whose wounds were assessed weekly using computerised wound analysis for four weeks or until debrided. Debridement was identified when there was 80% red granulating tissue present and no sign of necrosis. There were no statistically significant differences in comfort, wound odour, surrounding skin condition of time to debridement between the two groups.




Fear, M., Thomas, S, Dr., Mid-Glamorgan Health Authority. IntraSite Gel compared with Debrisan paste in the management of pressure sores.


A wide range of products is currently available for the management of yellow sloughy wounds. Two of the most frequently used products are IntraSite Gel and Debrisan Paste. However these materials have not been compared previously in a controlled clinical evaluation.


To compare clinical performance, cost effectiveness and user acceptability of two widely used desloughing/cleansing agents in the management of pressure sores. Dressings
IntraSite Gel is a sterile amorphous hydrogel, containing polymer, water and propylene glycol.

Debrisan paste is a ready-mixed paste formulation consisting of dextranomer, polyethylene glycol 600 and water. According to the instructions, gauze dressings should be used in conjunction with paste to form a 'package' which lies within the wound itself.
Both dressings were converted using a perforated plastic film, absorbent dressing and retained using tape/bandages as appropriate.


40 patients with grade 3 or grade 4 pressure sores containing significant quantities of yellow/brown slough were recruited into the study and randomised to treatment.
All wounds were cleaned with normal saline. Dressings were applied according to the manufacture's instructions.

Within the limits defined in the study protocol, frequency of dressing changes was left to the clinical judgement of the investigator.
Patients continued in the study until their wound has been fully cleansed, or for a maximum of 28 days.


Assessments were made at each dressing change.




Mehtar, S, Dr., Mayet, F. A pilot study of IntraSite Gel in the management of infected wounds

A pilot study of IntraSite Gel in the management of clinically infected wounds was carried out at the North Middlesex Hospital in London.

Five patients with a variety of clinically infected wounds were recruited to the study. One patient had 2 wounds, making a total of six wounds evaluated during the study period.
All patients were treated using systematic antibiotics. Non-occlusive secondary dressings were used, and in the majority of cases dressings were changed on a 24 hourly basis. All six wounds treated went through to a stage were the infection was said to have resolved.

The study demonstrates that clinically infected wounds can be successfully treated through a resolution of infection using IntraSite Gel, when the manufacturers guidelines for using are followed.




Westerhof, W, Dr., Mekkes J, R. IntraSite Gel under occlusion in Infected wounds
Between March and June 1991, four patients with difficult non healing wounds were treated with IntraSite Gel under occlusion. This report contains details of the wound and patient history.
In each case, IntraSite Gel removed necrotic tissues very effectively and was found to be comfortable for the patient. The debriding effect of IntraSite Gel under occlusion was considered to be better than the soaked gauze (changed three times per day).




D Krasner, Using a hydrogel foam and dressing retention sheet
A nurse may sometimes feel better able to evaluate a specific dressing if placed in the position of the patient experiencing the results first-hand. Recently an ET nurse had this opportunity when she became involved in her own wound care following abdominal surgery. The following case study chronicles the topical management of her abdominal wound and describes a diagnosis that was radically different from that suggested by the original symptoms.




Vernon,T. IntraSite Gel - Its use in the Treatment of Excoriation. EWMA conference 1999
3 case studies to illustrate how IntraSite Gel can be used in the management of excoriation caused by either urinary or faecal incontinence. The results showed improvement after several days application. More clinical investigation into the properties of IntraSite Gel for this indications needs to be conducted for healthcare professionals to base their practice on evidence based medicine.




Westerhof, W, Dr., Mekkes, J,R. Academisch Medisch Centrum: A Pilot Study comparing IntraSite Gel with saline soaked gauze for wound debridement
A pilot study comparing the performance of IntraSite Gel and saline soaked gauze as debriding agents in the management of necrotic wounds. Ten patients with venous leg ulcers were treated and evaluated during the 7 day study period. Five patients were treated using IntraSite Gel, 5 using saline soaked gauze. IntraSite Gel was changed on a daily basis, saline soaked gauze three times daily. The study demonstrates, using quantifiable measures, that IntraSite Gel is an effective debriding agent, and offers a number of perceived advantages/benefits over the centre's standard saline soaked gauze regime.