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CUTINOVA Hydro

HYDRO-SELECTIVE Wound Dressing

Product Introduction

CUTINOVA Hydro  is a HYDRO-SELECTIVE, self adhesive sterile wound dressing consisting of two layers - a polyurethane gel matrix and a polyurethane top-film which is waterproof and acts as a bacterial barrier

CUTINOVA Hydro offers the following benefits:


Clear

CutinovaHydro Hydro Selective Dressing Product Information Clear1

One of the clear advantages of CUTINOVA Hydro is that it is semi-transparent. Semi transparency allows observation of the underlying wound, without the need for unnecessary dressing changes or disturbance of the wound1.   


CutinovaHydro Hydro Selective Dressing Product information Clear Time Saved

This means a wound can be generally observed without removing the dressing1. As a consequence of this, the need for unnecessary dressing changes is reduced and so the wound is disturbed less often1. These clear benefits of CUTINOVA Hydro also save valuable nursing time1.

 
Cleaner

CutinovaHydro Hydro Selective Dressing Product Information Cleaner

Waterproof and bacterial barrier 'Super absorbent particles' within the polyurethane gel matrix lock in excess wound fluid, even under compression3..CUTINOVA Hydro is the clean choice because it absorbs fluid without breaking down into the wound.

CUTINOVA Hydro absorbency

CutinovaHydro Hydro Selective Dressing Product Information Cleaner Cutinova Hydro absorbency 

This picture shows that the superabsorbent polymer in CUTINOVA Hydro not only absorbs excess wound fluid but also holds it in, thereby preventing leakage and reducing the risk of wound maceration, even under compression3,4. 

CutinovaHydro Hydro Selective Dressing Product Information Cleaner Wound Condition CUTINOVA Hydro Removal

The image shows how the polyurethane gel matrix of CUTINOVA Hydro stays intact, leaving no gel or dressing residue in the wound when CUTINOVA Hydro is removed1,2.

CutinovaHydro Hydro Selective Dressing Product Information Cleaner More Pleasant Dressing

Compare this to a hydrocolloid being removed and you can see why the ability of CUTINOVA Hydro to lock in water is such a clear advantage over hydrocolloids, assuring cleaner, more pleasent dressing changes1,2. In addition, the polyurethane top-film of CUTINOVA Hydro provides a barrier against water and bacteria but still allows water vapour and gaseous exchange, creaing a moist wound-healing environment3,4. All of these factors help ensure that CUTINOVA Hydro is the clear successor to hydrocolloids.


Fresher

CutinovaHydro Hydro Selective Dressing Product Information Fresher

Locked in wound fluid reduces the risk of maceration 1, and incidence of leakage
Does not break down into a gel - a common source of odor from wounds managed with hydrocolloids3,5. CUTINOVA Hydro does not break down into a messy gel, a common source of odour from wounds treated with hydrocolloids5. The diagram below shows how the superabsorbers within the polyurethane matrix of CUTINOVA Hydro lock in and hold onto absorbed fluid.

CUTINOVA Hydro superabsorbers

CutinovaHydro Hydro Selective Dressing Product Information Fresher Superabsorbers

The polyurethane matrix of CUTINOVA Hydro contains no gelling agents such as pectin or gelatin and, because CUTINOVA Hydro does not break down into a messy gel, there is no resulting gel odour - a clear advantage over hydrocolloids.


HYDRO-SELECTIVE

CutinovaHydro Hydro Selective Dressing Product Information Hydro selective

CUTINOVA Hydro selectively absorbs mainly water from wound exudate, but leaves the patient's own growth factors and proteins in the wound 6. Growth factors and other natural proteins are known to be essential agents in wound healing 7

See below for two activated animations demonstrating one of the most innovative features of CUTINOVA Hydro - it is HYDRO-SELECTIVE. This means that CUTINOVA Hydro can selectively absorb mainly water leaving agents important to healing, such as essential growth factors and other proteins, in the wound 6.

Selective Absorption



Press F5 to view the animation again.
This animation demonstrates the unique ability of CUTINOVA Hydro to absorb mainly water into its polyurethane gel matrix leaving essential wound healing agents, such as growth factors, in the wound.

 Normal Dressing



Press F5 to view the animation again. This animation demonstrates the normal mode of action of  Traditional Dressings which are not selective in terms of absorbency. The ability of CUTINOVA Hydro to selectively absorb mainly water from wound fluid has been demonstrated in an in vitro study6. The graph below shows how CUTINOVA Hydro outperformed other dressings in their ability to absorb mainly H2O from artificial wound fluid (i.e. human plasma) while leaving serum proteins behind6. The bars represent the concentration of protein and growth factors left in the wound. These are higher (i.e. a greater concentration) for CUTINOVA Hydro than for the two hydrocolloids used as comparisons.



CUTINOVA Hydro Hydro Selective Hydrocolloids Comparison

Science

Traditional dressings

Excess fluid production has always been an issue with wounds such as leg ulcers and pressure ulcers. This results from a combination of interstitial fluid being released from damaged tissue and exudate being released from the blood stream as a secondary effect of inflammation. Wounds such as leg ulcers and pressure ulcers (sometimes refered to as chronic wounds or wounds healing by secondary intention) are frequently in a state of inflammation and one of the effects of the inflammatory response is vasodilation. This in turn results in an increase in the amount of exudate released from the blood stream.

The production of fluid from chronic wounds is often considered a bad thing and most dressings seek to address this by absorbing wound exudate. Wound fluid, however, is not altogether bad. Among the constituents of exudate are growth factors, enzymes and other proteins that are essential to wound healing 6. One role of certain growth factors is to stimulate wound repair, while enzymes are involved in both the breakdown of dead tissue (necessary for wound healing) and the regulation of tissue breakdown. Other proteins, such as collagen, are crucial to normal wound healing.

Traditional dressings are not selective in terms of what they absorb (see animation below). Factors that stimulate healing will be taken into the body of a traditional dressing along with the wound fluid. CUTINOVA Hydro, however, selectively absorbs mainly water, leaving elements that are essential to wound healing, such as growth factors and other natural proteins, in the wound 6. Traditional Dressings are not selective in terms of what they absorb.



Press F5 to view the animation again



Selective Absorption

The animation below demonstrates one of the most innovative features of CUTINOVA Hydro - it is HYDRO-SELECTIVE. This means that CUTINOVA Hydro can selectively absorb mainly water leaving essential growth factors and other natural proteins important to healing in the wound.

 
Press F5 to view the animation again

 

Growth Factors

Growth factors are small, naturally occurring proteins (or peptides) which direct a range of biological processes. They are released by a variety of different cells that use them to stimulate, stop or mediate cellular events. A growth factor can trigger an effect in the cell that released it (autocrine signalling), in a neighboring cell (paracrine signalling) or over longer distances, in effector cells via the blood stream (endocrine or hormonal signaling). These protein signaling agents are known to play a significant role in wound repair. They are centrally involved in stimulating and controlling many wound healing processes; including inflammation, epithelialization (the generation of new epidermal skin), fibroplasia (the formation of granulation tissue), angiogenesis (the formation of new blood vessels) and scar formation 7. Phagocytic cells, called macrophages, synthesise many growth factors involved in the wound healing process. When these cells are removed from a wound, healing is markedly decreased.

Growth factors commonly have long names, such as basic fibroblast growth factor or platelet-derived growth factor, which are frequently shortened to a series of letters and sometimes numbers, for example bFGF (basic fibroblast growth factor) and PDGF (platelet-derived growth factor). The ability of CUTINOVA Hydro to selectively absorb mainly water from wound fluid leaving essential growth factors and other proteins in the wound, has been demonstrated in an in-vitro study 6.

The graph below shows how CUTINOVA Hydro outperformed other dressings in their ability to absorb mainly H 2O from artificial wound fluid (i.e. human plasma) while leaving serum proteins behind 6. The bars represent the concentration of protein and growth factors left in the wound. These are higher (i.e. a greater concentration) for CUTINOVA Hydro than for the two hydrocolloids used as comparisons.


CutinovaHydro Hydro Selective Dressing Science Selective Absorption Outperformance Graph

Traditional dressings are not selective in the way in which they absorb fluid. In other words they will indiscriminately absorb wound fluid and its contents.

For References, see the Abstracts tab. 

Abstracts

Click on any of the following titles to view a summary of the paper.

  1. McMullen D, Corazza C, Watson H. Clinical Experience with a Hydroactive Dressing to Treat Stage II Cutaneous Ulcers. Data on file.
  2. Böttcher K. Experiences with the use of a Hydroactive Wound Dressing on Ulcers of Different Origin. Klinik Magazin 1991; Nr 2/3.
  3. Andersson E. Report on Experiences with a new Hydroactive Wound Dressing for Treating Leg Ulcers. Klinik Magazin 1991; No 12.
  4. Hutter MJ. Experiences with a Hydroactive Wound Dressing Vasomed aktuell 1991; No 4.
  5. Thomas S. Hydrocolloids: A guide to the composition, properties and use of hydrocolloid dressings and the commercial presentations available. Journal of Wound Care 1992; 1: 2.
  6. Achterberg V, Welling C, Meyer-Ingold W. Hydroactive dressings and serum proteins: an in vitro study. Journal of Wound Care 1996; 5: 2.
  7. Krishnamoorthy L, Morris HL, Harding KG. A dynamic regulator: the role of growth factors in tissue repair. Journal of Wound Care 2001;10(4):99-101.

FAQs

1. What does 'CUTINOVA' mean?

CUTINOVA is derived from the Latin for 'new skin' (cutis = skin, nova = new).

 
2. What is selective absorption?

Selective absorption is the process by which CUTINOVA Hydro takes up mainly water from wound exudate, leaving the patient's own growth factors and other natural proteins in the wound 6. Growth factors and proteins are known to be essential agents in wound healing7.

Growth factors control the whole process of healing, from early inflammation, through to wound closure. They are an especially important component of wound fluid and occur naturally in wound exudate 6. Enzymes are necessary for wound debridement and to allow cell movement through tissue, enabling blood vessel growth and re-epithelialisation to occur. Extracellular matrix molecules facilitate cell movement and are essential for the building of new tissue, giving the healing wound structural integrity.

Selective absorption enables CUTINOVA Hydro to concentrate these proteins in the wound fluid rather than taking them up into the dressing. This effect has been demonstrated in vitro, where CUTINOVA Hydro showed an approximate two-fold increase in the concentration of proteins in artificial wound fluid6.


3. Do other dressings selectively absorb?

CUTINOVA Hydro has been proven to significantly increase the concentration of both protein and growth factors in wound fluid. Such concentrations have not been found with any other dressings tested6.


4. What are growth factors?

Growth factors are an especially important component of wound fluid and occur naturally in wound exudate6. They are a type of protein that help tissue repair by encouraging cell division and growth.


5. Why are growth factors important for wound healing?

Growth factors are important for wound healing because they promote cellular division and growth. They are an especially important component of wound fluid and occur naturally in wound exudate6. It is thought that growth factors initiate attraction of cells into the wound and are critical to all aspects of tissue repair7.


6. Does selective absorption help wound healing?

The selective absorption of CUTINOVA Hydro means that the patient's own growth factors are concentrated in the wound. Growth factors help to make a contribution to the rate of wound healing. The process of selective absorption might therefore explain the beneficial effects of CUTINOVA Hydro in the healing of wounds.

 
7. How do chronic wounds differ from acute wounds in terms of growth factors?

Chronic wounds have lower levels of important growth factors than acute wounds. This could be one of the reasons why chronic wounds can take longer to heal.


8. Can growth factors be put into the wound?

Yes. Growth factors can be applied topically as drugs to stimulate the wound healing process. However, CUTINOVA Hydro concentrates the body's own growth factors.


9. How does CUTINOVA Hydro selectively absorb?

CUTINOVA Hydro is composed of a special polyurethane matrix, which has a high water-absorbing capacity and low protein absorbing capacity. CUTINOVA Hydro is specifically designed to attract and hold water molecules. This means that CUTINOVA Hydro selectively takes up mainly water, leaving the patients own growth factors and other proteins behind in the wound.

 

10. Will the swelling of CUTINOVA Hydro cause trauma/pressure on the wound bed?

No, CUTINOVA Hydro does not cause pressure on the wound bed because the dressing swells in a controlled manner.


11. Can CUTINOVA Hydro debride?

CUTINOVA Hydro promotes autolytic debridement as it is a moist wound healing dressing. However, Smith & Nephew offers products specifically for wound debridement and wound bed preparation.


12. What is the wear time of CUTINOVA Hydro?

CUTINOVA Hydro can be left in place for up to 7 days, depending on the nature of the wound and the level of exudate.


13. How can the edges be held down to prevent the dressing from lifting when used in awkward places?

CUTINOVA Hydro can be secured in place with OPSITE FLEXIFIX around the edges of the dressing.

 
14. Can CUTINOVA Hydro be used in conjunction with hydrogels?

CUTINOVA Hydro can be effectively used in combination with hydrogels such as INTRASITE Gel.


15. Does selective absorption mean that the wound is left dry?

No, water is absorbed in a controlled manner to ensure a moist, wound healing environment is always maintained. CUTINOVA Hydro absorbs only excess water, so will not dry out a wound.


16. Is CUTINOVA Hydro occlusive?

No, CUTINOVA Hydro is semi-occlusive. It is waterproof and acts as a bacterial barrier, but allows the transpiration of water vapour, thereby avoiding maceration.


17. Does CUTINOVA Hydro cause any maceration of the peri-wound skin?

CUTINOVA Hydro selectively absorbs excess water from the wound bed which is then bound within the polyurethane matrix. It cannot be squeezed out even under compression. CUTINOVA Hydro has therefore been shown to reduce the risk of maceration1.


18. When should I use CUTINOVA Hydro?

CUTINOVA Hydro is a clean successor to hydrocolloids, as it does not break down in the wound. CUTINOVA Hydro offers the benefits of a hydrocolloid, but also offers a clean, fresh and advanced treatment.

 
19. What types of wounds can CUTINOVA Hydro be used on?

CUTINOVA Hydro is indicated for use on leg ulcers, pressure ulcers, superficial and partial thickness burns and diabetic foot ulcers, where the surrounding skin is intact.


 20. Does CUTINOVA Hydro adhere to the wound?

CUTINOVA Hydro is inherently adhesive, but loses this quality when it comes into contact with wound fluid. For this reason, it does not stick or adhere to the wound (provided that the dressing is used appropriately).


21. Can CUTINOVA Hydro be used under compression?

CUTINOVA Hydro absorbs and retains fluid even under compression. Fluid is absorbed and then bound within the matrix, making it suitable for use under compression.


22. Are any of the ingredients in CUTINOVA Hydro of animal origin?

No. Unlike many hydrocolloids, CUTINOVA Hydro does not involve any ingredients of animal origin.


23. How is CUTINOVA Hydro sterilized?

CUTINOVA Hydro is sterilized using gamma radiation.


24. What is the shelf life of CUTINOVA Hydro?

The shelf life of CUTINOVA Hydro is 5 years.

 
25. Can CUTINOVA Hydro be re-sterilized?

No. CUTINOVA Hydro should not be re-sterilized because it will become more sticky and adhesive. Each dressing is sterile and for single use only. If the pouch is damaged, the dressing should be discarded and not re-sterilized.


For References see the Abstracts tab