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Comparative evaluation of a...

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Rajput HI, Cullingworth L, Dunne T. Comparative evaluation of a hydrocellular foam wound dressing (Allevyn*) versus a hydrocolloid dressing in chronic lower limb venous ulceration. Association of Surgeons of South Africa Congress, 2000. South African Journal of Surgery 2001


Type of Study: Randomised Controlled Trial


Type of Wound: Venous Leg Ulcers



A randomised controlled study of 100 patients, (aged between 18 and 80 years old), attending a venous ulcer clinic, comparing Allevyn and a hydrocolloid dressing. The study was conducted over a period of 20 months.
Granulating ulcers were dressed according to randomisation and a compression bandage applied.
Ulcer size was measured at the initial visit and all subsequent visits. The healing process was assessed over an 8-week period.
Analysis was conducted on 81 ulcers less than 25 sq cm.
The primary endpoint of the study was rate of healing.

Key Findings

  • Allevyn demonstrated significant superiority in the number of healed venous leg ulcers of less than 25cm 2 over an eight-week period, 41% vs. 22% respectively (p < 0.05).
  • Fewer dressing changes were required in the patients treated with Allevyn dressings. Per ulcer healed: 8.9 dressing changes were required in the Allevyn arm of the study, and 11.1 in the hydrocolloid arm.
  • Allevyn was extrapolated as being more cost effective than hydrocolloid dressings in the management of chronic venous ulceration of the leg.