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Abstract #8

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Iodosorb* 0.9% Cadexomer Iodine



J.W. Harcup, P.A. Saul
British Journal of Clinical Practice (1986) 40 (9) 360- 364



A Study of the Effect of Cadexomer Iodine in the Treatment of Venous Leg Ulcers


Clinical Paper Abstract

Cadexomer iodine is a highly hydrophilic three-dimensional network of a modified starch polymer, containing iodine (0.9% w/w) physically immobilised within the matrix. It is used in the management of exuding venous ulcers. A total of 72 patients with exuding chronic venous ulcers of the lower limbs were entered into a multicentre randomised optional cross over trial using cadexomer iodine or a standard treatment. The patients had their ulcers managed entirely in the community by general practitioners. The trial continued for eight weeks or until the ulcer had healed. At the midpoint of the trial (fourth week), 20 patients changed therapy, 18 to cadexomer iodin e and 2 to standard therapy (p < 0.01). Of the 14 patients whose ulcers were healed after eight weeks, 13 were using cadexomer iodine and one was using standard therapy (p < 0.005).


At week 4, cadexomer iodine produced significant improvement over standard therapy for all criteria measured. These were: ulcer size (p < 0.01), oedema (p < 0.05), erythema (p < 0.05), exudate (p < 0.001), odour (p < 0.01), pus and debris (p < 0.05) and pain (p < 0.005).


Slough Removal Antibacterial Efficacy Sustained Antibacterial effect Exudate Management Effective Wound Healing Odour Patient Comfort Cost/Time Savings Sensitivity