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Abstract #20

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Iodosorb* 0.9% Cadexomer Iodine

 

 

L. Hillstrom
Acta Chir Scand Suppl 544: 53-56 - 1988

 

 

Iodosorb Compared to Standard Treatment in Chronic Venous Leg Ulcers - A Multi Centre Study

 

Clinical Paper Abstract

A randomised multicentre study comparing Iodosorb (cadexomer iodine) and standard treatment in outpatients with chronic venous leg ulcers. 10 centres were used for the study and 93 patients with long standing venous ulcers entered the study. The patient inclusion criteria were that the ulcer had to be present for at least three months with a minimum diameter of 2cm. Patients with non-venous primary cause of ulcers were excluded as well as patients with co-existent metabolic disease, history of iodine sensitivity, suspected malignancy or topical or systemic treatment with iodine containing drugs.

 

Assessments were performed after 1, 2 4 and 6 weeks of treatment. 21 of the 93 patients were excluded for various reasons. After one week of treatment with cadexomer iodine the mean ulcer size reduced significantly and continued to decrease during the 6 weeks of the trial. With standard treatment a certain decrease in ulcer size was observed during the first week of treatment but was not maintained. After 6 weeks of treatment the mean ulcer size in the cadexomer iodine group had reduced by 35% and in the standard group it had increased slightly (by 5%).

 

The effect of cadexomer iodine on stimulating granulation and reducing erythema of surrounding skin was significantly greater than the standard treatment. The most dramatic difference between the two treatments was observed in removal of pus and debris. Staphylococcus aureus was the most frequently isolated organism during the trial and after 6 weeks the number of isolates was significantly lower after application of cadexomer iodine. Significant differences in favour of cadexomer iodine were also observed for reduction of pseudomonas aeruginosa and other organisms. The results of the trial suggest that in outpatient treatment of chronic venous ulcers, despite adequate compression bandages, the choice of topical agent may significantly influence healing.

 

Slough Removal Antibacterial Efficacy Sustained Antibacterial effect Exudate Management Effective Wound Healing Odour Patient Comfort Cost/Time Savings Sensitivity
X X X X X