‡ In these countries please contact our distributor

Abstract #2

Smith & Nephew logo
Iodosorb* 0.9% Cadexomer Iodine



M.C. Ormiston, M.T.J. Seymour, G.E. Venn, R.I.
Cohen, and J.A. Fox
In Cadexomer Iodine JA Fox, H Fischer, Eds. 1983; 63-69



A Randomised Comparison of Cadexomer Iodine and a Standard Treatment in Out- Patients with Chronic Venous Ulcers


Clinical Paper Abstract

An interim analysis of a study to compare the effectiveness of cadexomer iodine and a standard antiseptic dressing for chronic venous ulcers. Patients in the trial were confined to those whose ulcers had not healed after at least 3 months of treatment. All ulcers measured at least 2cm in diameter. Minimum age was 21 years. Non venous and mixed ulcers were excluded from the study. 54 patients had completed the study at time of analysis. There were 27 patients in the cadexomer iodine group and 27 in the standard group. The mean duration of the ulcers was 52 months in the former group and 20 months in the latter. Re-epithelisation was faster in the ulcers treated with cadexomer iodine. This difference was significant after 6 weeks.


A statistical analysis was performed of different methods of calculating re-epithelialisation to eliminate possible bias relating to differences in mean ulcer size. With all methods cadexomer iodine showed a superior effect. Those treated with cadexomer iodine also showed significantly faster reduction of pus and debris and of pain from two weeks onwards. Although it was concluded that the correct assessment of the underlying circulation disturbance and well applied compression bandaging are the most important aspects of management of venous ulcers, the ulcers treated with cadexomer iodine showed significantly more rapid desloughing and healing than those treated with a standard dressing.


Slough Removal Antibacterial Efficacy Sustained Antibacterial effect Exudate Management Effective Wound Healing Odour Patient Comfort Cost/Time Savings Sensitivity