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Iodosorb* Abstract 7

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Iodosorb Cadexomer Matrix with Iodine


Treatment of Venous Leg Ulcers with Cadexomer Iodine with Particular Reference to Iodine Sensitivity

C.Floyer, J.D. Wilkinson.

Acta Chir Scand Suppl 544: 60-61 1988



This study was set up primarily to establish the safety of cadexomer iodine ( Iodosorb) as far as the development of sensitivity was concerned. During the trial period the response to cadexomer iodine when employed as part of the treatment regimen for venous leg ulcers was examined. Initially, patch tests were performed on all 30 patients. There were no cases of sensitivity and none developed during the trial. Measurements for the leg ulcers were made during the trial to determine the degree of healing. 30 patients commenced the trial, which lasted 12 weeks. 19 patients completed the trial. Visits were at 0, 1, 3, 6 and 12 weeks. At each visit an assessment was made and at weeks 0, 6 and 12, measurements were taken of the ulcer size. In all patients that completed the trial, erythema, exudate, pus and debris were reduced. In the 19 patients that completed the trial, pain from the ulcer was reduced over the trial period in 14 patients. Cadexomer iodine was found to cause no allergic reactions. A stinging reaction occurred that did cause withdrawal from the trial but in patients completing the trial, pain was usually reduced.