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Exudate

Excessive exudate can:

  • Lead to prolonged inflammation and tissue maceration1
  • Slow down or even prevents cell proliferation2
  • Interfere with growth factor availability3-4
  • Containselevated levels of inflammatory mediators and activated matrix metalloproteinase (MMPs)3,4

IODOSORB and IODOFLEX absorb exudate5-10

  • Possess high absorption capacity to help establish moisture balance: absorbs up to 6 times
  • Numerous clinical studies support the highly effective
    absorption capacity of IODOSORB6-8,11-13

 
Evidence

Paper Study type Results
Ormiston8 RCT (24 weeks) - Chronic VLU - CI vs. SC CI had an improvement in exudate (p<0.001)
Hansson13 RCT (12 week) – VLU - CI vs. hydrocolloid or paraffin gauze CI ceased exudation in 70% ulcers compared to 52% and 44% with hydrocolloid or paraffin gauze
Troeng7 RCT (18 weeks) – VLU - CI vs. SC CI significantly reduced exudation
Lindsay11 RCT (10 wks) – VLU - CI vs. SC CI had significant improvement in exudation reduction vs. SC (p<0.002)
Johnson12 Open-label, single arm study – treatment of infected wounds – CI CI controlled exudate levels effectively, minimising redressing to every third day
Drosou14 Review of clinical studies CI reduced exudate in all studies
Skog15 RCT (6 wks) – VLU - CI vs. SC CI significantly reduced exudate vs. SC (p<0.005)
Sundeberg6 Review of clinical studies CI is effective at promoting wound healing through exudate reduction

 


References
1. WUWHS. Principles of best practice: Wound exudate and the role of dressings. A consensus document. World (2007).
2. Bucalo B, et al. Wound Repair Regen. 1993; 1:181–186.
3. Trengove NJ, et al. Wound Repair Regen 1996; 4:234–9.
4. Yager DR, et al. Invest. Dermatol 1996; 107: 743–748.
5. Zamora JL. Am J Surg. 151:400-406 (1986).
6. Sundeberg J, Meller R. Wounds. 9:68-86 (1997).
7. Troeng T, Skog E, Arnesjo B, et al., In: Fox JA, Fischer H, eds. Cadexomer Iodine. New York, NY: F.K. Schattauer Verlag: 43-50 (1983).
8. Ormiston MC, Seymour MTJ, Venn GE, et al., In: Fox JA, Fischer H, eds. Cadexomer Iodine. New York, NY: F.K. Schattauer Verlag; 63-69 (1983).
9. Enoch S, Harding K. Wounds. 15:213-229 (2003).
10. Salman H, Leakey A. Report number 194-03-01 (2001).
11. Lindsay G, Latta D, Lyons KGB, Livingstone ED, Thomson W. Acta Ther. 12:141-148 (1986).
12. Johnson A. Prof Nurse. 7:60-64. (1991).
13. Hansson C. Int J Dermatol. 37:390-396(1998).
14. Drosou A, et al. Wounds. 2004;15:149–166.
15. Skog E, Arnesjo B, Troeng T, et al., Br J Dermatol.109:77-83 (1983)