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Slough

Slough and soft necrotic tissue impedes naural healing1,2

  • Non-viable necrotic or compromised tissue/ adherent fibrous material derived from proteins, fibrin and fibrinogen – usually moist, creamy yellow appearance1
  • Prevent migration of cells2
  • May sequester growth factors2

IODOSORB and IODOFLEX absorb exudate3-8

  • Possess high absorption capacity to help establish moisture balance: Absorbs up to 6 times
  • Numerous clinical studies support the highly effective absorption capacity of IODOSORB9-11

Evidence

Paper Study type Results
Moberg12 RCT (8 wks) - Pressure ulcer CI had a significant improvement in pus and debris (p=0.005) vs. SC
Harcup13 RCT (8 wks) – VLU CI had significant improvement in pus and debris at 4 and 8 weeks vs. SC (p<0.05)
Lindsay9 RCT (10 wks) – VLU CI offered a statistically significant reduction in pus vs. SC (p<0.002)
Skog14 RCT (6 wks) – VLU A significant difference in mean VAS scores between CI and SC for pus and debris (p<0.005) was shown at 6 weeks
Hansson15 RCT (12 week) – VLU CI resulted in significantly less slough at 4 and 8 weeks vs. paraffin gauze (p<0.05)
Laudanska16 RT (6 weeks) – VLU CI resulted in significantly less pus and debris at 6 weeks vs. SC (p<0.05)

References
1.Tong, AJ. Wound Care 1999; 8: 338–339.
2. Falanga, V et al. J. Invest. Dermatol 1994; 102: 125–127.
3. Zamora JL. Am J Surg. 151:400-406 (1986).
4. Sundberg J, Meller R. Wounds. 9:68-86 (1997).
5. Troeng T, Skog E, Arnesjo B, et al., In: Fox JA, Fischer H, eds.Cadexomer Iodine. New York, NY: F.K. Schattauer Verlag: 43-50 (1983).
6. Ormiston MC, Seymour MTJ, Venn GE, et al., In: Fox JA, Fischer H, eds. Cadexomer Iodine. New York, NY: F.K. Schattauer Verlag; 63-69 (1983).
7. Enoch S, Harding K. Wounds. 15:213-229 (2003).
8. Salman H, Leakey A. Report number 194-03-01 (2001).
9. Lindsay G, Latta D, Lyons KGB, Livingstone ED, Thomson W. Acta Ther. 12:141-148 (1986).
10. Johnson A. Prof Nurse. 7:60-64. (1991).
11. Hansson C. Int J Dermatol. 37:390-396(1998).
12. Moberg S, et al. J. Am. Geriatr. Soc 1983; 31: 462–465.
13. Harcup et al. Br. J. Clin. Pract. 1986; 40: 360–4.
14. Skog E, Arnesjo B, Troeng T, et al., Br J Dermatol.109:77-83
15. Hansson, C. et al. Int. J. Dermatol 1998; 37: 390–396.
16. Laudanska, HJ. Int Med Res. 1988; 16, 428–35.