Paper title: CICA-CARE gel sheeting in the management of hypertrophic scarring.
Author: Carney SA, Cason CG, Gowar JP, Stevenson JH, McNee J, Groves AR, Thomas SS, Hart NB, Auclair P.
Reference: Burns (1994); 20:163-167
Study abstract: A prospective, controlled clinical trial was undertaken to assess the efficacy and safety of two types of silicone gel, SILASTIC Gel Sheeting (SGS) and CICA-CARE, in the management of hypertrophic scars. Forty-two patients were randomly assigned to SGS and CICA-CARE groups and their hypertrophic scars were divided into treated and control areas. Extensometric measurements were made at monthly intervals for 6 months and significant improvement of the treated areas relative to the control areas was observed. The two gels were not significantly different in efficacy or safety, but CICA-CARE, being more adhesive and more conformable than SGS, has advantages in ease of use and patient acceptability.
SILASTIC is a Trade Mark of Dow Corning
Paper title: Comparison of two types of silicone gel sheets
Author: Donald L
Reference: Australian/New Zealand Burns Association. Issue no. 16, 14 August 1995, page 10-11
Study abstract: To determine whether there is a difference in (a) durability, (b) complications, (c) effectiveness between traditionally used SPENCO silicone gel sheets compared with CICA-CARE gel sheets in the treatment of hypertrophic and keloid scars.
SPENCO is a Trade Mark of Spenco Medical Corporation
Paper title: Silicone gel in scar treatment
Author: K J Quinn
Reference: Burns (1987) 13, S33-S40
Study abstract: The purpose of the study was to determine whether silicone gel (SILASTIC Gel Sheeting) reduces hypertrophic scarring, and to investigate its mode of action and any other possible applications. Silicone gel was applied to 125 patients with 129 hypertrophic keloid scars. Scar improvement was rated after two months on the basis of texture (measured by an extensometer), colour and thickness. There was an improvement in one or two of these criteria in 65 cases and in all three in 10 cases, while 37 patients did not return for follow-up. Adverse events noted were pruritis and rash, which could be eliminated with daily or more frequent washing of scar and gel. In three cases, tissue breakdown occurred, and it is recommended by the author that the gel should not be applied until epidermal healing is complete, and that the important of frequent washing of the scar and gel should be emphasised to patients.
The possible modes of action of silicone gel have been investigated, and it has been concluded that pressure, temperature, oxygen tension and occlusion are not involved. The possibility of formation of a water reservoir in the stratum corneum has been suggested, and it has been shown that a silicone liquid is leached from the gel, although whether this penetrates the stratum corneum is not known. The mechanical properties of silicone gel have also been investigated, and it was shown that the material has similar extensibility to skin, that it is inert and impermeable to the micro-organisms tested, and that it has a water vapour transmission rate approximately half that of skin.
The author describes her experience of the use of silicone gel in five patients with unhealed burn wounds. The results in this small series indicated that silicone gel is easy to apply and comfortable, and may be beneficial in partial thickness burn wounds.